In multi-cell massive distributed wireless communication system, the relationship between the optimal downlink energy efficiency (EE) and the number of remote access units (RAUs), the number of user antennas, the number of cells and the transmitting power of multiple cells is studied. First, according to the distance between RAU and user, the analytic formula of system throughput is derived. Then, the downlink EE optimization model is established based on the relationship between the actual power consumption parameters and the composite channel, which includes path loss, shadow fading and multipath fading. Finally, based on this, the relationship between the EE and some impact factors including the number of RAUs, the number of user antennas, the number of cells and the transmitting power is deduced, meanwhile the corresponding algorithm is proposed to maximize the EE. Theoretical analysis and simulation results verify that the correctness of the relationship between system EE and multiple related parameters, and the proposed system EE optimization algorithm also has the advantage of low iteration times.